Updated in Mai. 2017







A man may die, nations may rise and fall,

but an idea lives on. John F. Kennedy



Independent Research:

23. Scesa, P.; Wangpaichitr, M.; Savaraj, N.; West*, L.; Roche*, S. P. Chem. Int. Ed. (communication) work under review 2017 “Kinetic Dearomatization Strategy for an Expedient Route to Bielschowskysin ”

22. Samanta, S. S.; Roche*, S. P. J. Org. Chem. (full article) work under review 2017. “In Situ-Generated Glycinyl Chloroaminals for a Verstatile One-Pot Synthesis of Non-Proteinogenic a-Amino Esters



21. Hall, A.; Roche*, S. P.; West*, L. Org. Lett. 2017, 19, 576–579. “Synthesis of Briarane Diterpenoids: Biomimetic Transannular Oxa-6p electrocyclization Induced by a UVA/UVC Photoswitch.” Link


20. Jeedimalla, N.; Flint, M.; Smith, L.; Haces, A.; Minond*, D.; Roche*, S. P.  Eur. J. Med. Chem. 2015, 106, 167–179 “Multicomponent Assembly of 4-Aza-podophyllotoxins: A Fast Entry to Highly Selective and Potent Anti-Leukemic Agents.”  Link


19. Wasa, M.; Liu, R. Y.; Roche*, S. P.; Jacobsen*, E. N. J. Am. Chem. Soc., 2014134, 13108 –13113. “Asymmetric Mannich Synthesis of a-Amino Esters by Anion-Binding Catalysis.Link








18. Roche*, S. P.; Samanta, S. S.; Gosselin, M. M. J. Chem. Commun. 2014, 50, 2632–2634 “Autocatalytic One Pot Orchestration for the Synthesis of α-Arylated α-Amino Esters.Link





17. Roche*, S. P.; Youte Tendoung, J.-J.; Tréguier, B.; Tetrahedron 2014, 70, “Advances in Dearomatization Strategies of Indoles.Review Article Link







16. Treguier, B.; Roche*, S. P. Org. Lett. 2014, 16, 278–281 A Double Annulative Cascade of Tryptophan Containing Peptides Triggered by Selectfluor®Link






15. Jeedimalla, N.; Johns, J.; Roche*, S. P. Tetrahedron Lett. 2013, 54, 5845–5848. “Mechanistic Investigation and Implications of a Sacrificial Aniline for the Tandem Cascade Synthesis of 4-Aza-podophyllotoxin Analogues.” Link





Graduate and Postdoctoral Research:

14. Santagata, S.; Mendillo, M. L.; Tang, Y-C.; Perley, C. C.; Roche, S. P.; Kwon, H.; Koeva, M.; Subramanian, A.; Golub, T. R.; Amon, A.; Porco Jr., J. A.; Whitesell *, L; Lindquist *, S. Science 2013, 341, 250–260. “Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state.” Link (2 citations)

13. Lajkiewicz, N. J.; Roche, S. P.; Gerard, B.; Porco Jr.*, J. A. J. Am. Chem. Soc., 2012134, 13108 13113. “Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline. Link (5 citations)

12. Porco Jr., J. A.; Pelletier, J.; Roche, S. P.; Cencic, R.; Rodrigo, C. PCT Int. Appl. (2011), WO 2011140334 A2 20111110  “Preparation of rocaglamide derivatives as antiproliferative agents Link

11. Rodrigo, C. M.; Cencic, R.; Roche, S. P.; Pelletier, J.; Porco Jr.*, J. A. J. Med. Chem., 2012, 55, 558 562. “Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies”. Link (8 citations)

10. Roche, S. P.; Porco Jr.*, J. A. Angew. Chem. Int. Ed. 2011, 50, 40684093. Review: “Dearomatization Strategies in Complex Natural Product Synthesis” Link (85 citations)

9. Roche, S. P.; Cencic, R.; Pelletier, J.; Porco Jr.*, J. A. Angew. Chem. Int. Ed. 2010, 49, 6533 – 6538. “Biomimetic Photocycloaddition of 3-Hhydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation”. Link Selected by the editors as a “Hot Paper”(16 citations)

8. Roche*, S. P.; Aitken*, D. J. Eur. J. Org. Chem. 2010, 5339 – 5358. Review: “Chemistry of 4-Hydroxy-2-cyclopentenone derivatives”.  Link (7 citations)

7. Roche, S. P.; Teyssot, M-L.; Gautier*, A. Tetrahedron Lett. 2010, 51, 1265 – 1268. “Synthesis of 1,2 Diamines under Environmentally Benign Conditions: Application for the Preparation of Imidazolidiniums”. Link (5 citations)

6. Faure*, S.; Hjelmgaard, T.; Roche, S. P.; Aitken*, D. J. Org. Lett. 2009, 11, 1167 – 1170. “Passerini Reaction-Amine Deprotection-Acyl Migration Peptide Assembly: Efficient Formal Synthesis of Cyclotheonamide C”. Link (15 citations)

5. Teyssot, M-L.; Jarrousse, A-S.; Manin, M.; Chevry, A.; Roche, S.; Norre, F.; Beaudoin, C.; Morel, L.; Boyer, D.; Mahiou, R.; Gautier*, A. Dalton Trans. 2009, 6894 – 6902. Perspective: “Metal-NHC complexes: a survey of anti-cancer properties”. Link (105 citations)

4. Roche, S. P.; Faure, S.; Aitken*, D. J. Angew. Chem. Int. Ed. 2008, 47, 6840 – 6842. “Total Synthesis of Cyclotheonamide C using a Tandem Backbone-Extension–Coupling Methodology”. Link (5 citations)

3. Roche, S. P.; Faure, S.; El Blidi, L.; Aitken*, D. J. Eur. J. Org. Chem. 2008, 30, 5067 – 5078. “Total Synthesis of Cyclotheonamide C by Use of an α-Keto Cyanophosphorane Methodology for Peptide Assembly”. Link (4 citations)

2. Nicolaou*, K. C.; Majumder, U.; Roche, S.P.; Chen*, D. Y.-K. Angew. Chem. Int. Ed. 2007, 46, 4715 – 4718. “Construction of the “Left Domain” of Haplophytine”. Link (22 citations)

1. Aitken*, D. J.; Faure, S.; Roche, S. Tetrahedron Lett. 2003, 44, 8827 – 8830. “Synthetic approaches to the Southern Part of Cyclotheonamide C”. Link (14 citations)

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