Publications

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Updated in September 2022

"A man may die, nations may rise and fall,

but an idea lives on."  John F. Kennedy

Independent Research: 2011-present

36. Richaud, A. D.; Zaghouani, M.; Zhao, G.; Wangpaichitr, M.; Savaraj, N.; Roche, S. Exploiting the Innate Plasticity of the Programmed Cell Death-1 (PD1) Receptor to Design Pembrolizumab H3 Loop Mimics. ChemBioChem 2022, 23, Early View  https://doi.org/10.1002/cbic.202200449 

35. Richaud, A. D.; Zhao, G.; Hobloss, S.; Roche, S. P. Folding in Place: Design of b-Strap Motifs to Stabilize the Folding of Hairpins with Long Loops. J. Org. Chem. 2021, 86, 13535–13547 

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34. Roche, S. P. In the pursuit of (ald)imine surrogates for the direct asymmetric synthesis of non-proteinogenic α-amino acids. Synthesis 2021, 53, 2767–2776

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33. Roche, S. P. Recent Advances in Oxa-6π Electrocyclization Reactivity for the Synthesis of Privileged Natural Product Scaffolds. Organics 2021, 2, 376–387. Link

32. Scesa, P.; West, L. M.; Roche, S. P. Role of Macrocyclic Conformational Steering in a Kinetic Route toward Bielschowskysin. J. Am. Chem. Soc. 2021, 143, 7566–7577

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31. Richaud, A. D.; Roche, S. P. Structure–Property Relationship Study of N-(Hydroxy)Peptides for the Design of Self-Assembled Parallel β-Sheets. J. Org. Chem. 2020, 19, 12329–12342; Preprint ChemRxiv. DOI: 10.26434/chemrxiv.12486236.v1

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30. Zhao, G.; Samanta, S. S.; Michieletto, J.; Roche, S. P. A Broad Substrate Scope of aza-Friedel−Crafts Alkylation for the Synthesis of Quaternary a-Amino Esters. Org. Lett. 2020, 22, 5822–5827; Preprint ChemRxiv. DOI: 10.26434/chemrxiv.12111309.v1

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29. Bendelsmith, A. J.; Kim, S. C.; Wasa, M.; Roche, S. P.; Jacobsen*, E. N. Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis. J. Am. Chem. Soc. 2019, 141, 11414–11419

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28. Samanta, S. S.; Roche, S. P. Synthesis and Reactivity of a-Haloglycine Esters: Hyperconjugation in Action. Eur. J. Org. Chem. 2019, 6597–6605. Editor Choice Issue Cover: Link

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27. Zaghouani, M.; Bögeholz, L. A. K.; Mercier, E.; Wintermeyer, W.; Roche, S. P.  Total synthesis of (±)-fumimycin and analogues for biological evaluation as peptide deformylase inhibitors. Tetrahedron 2019, 75, 3216–3230. Editor Invitation for the Tetrahedron Young Investigator Award Issue.

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26. Shearer, C.; Desaunay, O.; Zorc, S.; Richaud, A. D.; Samanta, S. S.; Jeedimalla, N.; Roche, S. P.  Interrupted Knoevenagel Condensation for the Synthesis of Unsymmetrical Fused Tricyclic Dihydropyrans. Tetrahedron 2019, 130606  Link

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25. Lepir, T.; Zaghouani, M.; Roche, S. P.; Li, Y. Y.; Suarez, M.; Irias, M. J.; Savaraj, N. Nivolumab to pembrolizumab switch induced a durable melanoma response: A case report. Medicine, 2019, 98, e13804-e13810. Link

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24. Jeedimalla, N.; Jacquet, C.; Bahneva, D.; Youte Tendoung, J.-J.; Roche, S. P. Synthesis of α-Arylated Cycloalkanones from Congested Trisubstituted Spiro-epoxides: Application of the House–Meinwald Rearrangement for Ring Expansion. J. Org. Chem. 2018, 83, 12357–12373. Editor Choice Issue Cover

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23. Scesa, P.; Wangpaichitr, M.; Savaraj, N.; West, L.; Roche, S. P. Angew. Chem. Int. Ed. 2018 , 57, 1316 – 1321“A Kinetic Dearomatization Strategy for an Expedient Route to the Bielschowskysin Skeleton” Link

22. Samanta, S. S.; Roche, S. P. J. Org. Chem. (full article) 2017, 82, 8514 – 8526. “In Situ-Generated Glycinyl Chloroaminals for a Verstatile One-Pot Synthesis of Non-Proteinogenic a-Amino Esters” Link

21. Hall, A.; Roche*, S. P.; West*, L. Org. Lett. 2017, 19, 576 – 579. “Synthesis of Briarane Diterpenoids: Biomimetic Transannular Oxa-6p electrocyclization Induced by a UVA/UVC Photoswitch.” Link (2 citations)

20. Jeedimalla, N.; Flint, M.; Smith, L.; Haces, A.; Minond*, D.; Roche*, S. P.  Eur. J. Med. Chem. 2015, 106, 167 – 179 “Multicomponent Assembly of 4-Aza-podophyllotoxins: A Fast Entry to Highly Selective and Potent Anti-Leukemic Agents.” Link (3 citations)

19. Wasa, M.; Liu, R. Y.; Roche*, S. P.; Jacobsen*, E. N. J. Am. Chem. Soc. 2014134, 13108 – 13113. “Asymmetric Mannich Synthesis of a-Amino Esters by Anion-Binding Catalysis.” Link (12 citations)

18. Roche*, S. P.; Samanta, S. S.; Gosselin, M. M. J. Chem. Commun. 2014, 50, 2632 – 2634 “Autocatalytic One Pot Orchestration for the Synthesis of α-Arylated α-Amino Esters.” Link (2 citations)

17. Roche*, S. P.; Youte Tendoung, J.-J.; Tréguier, B.; Tetrahedron 2014, 70, “Advances in Dearomatization Strategies of Indoles.” Review Article Link (66 citations)

16. Treguier, B.; Roche*, S. P. Org. Lett. 2014, 16, 278 – 281 “A Double Annulative Cascade of Tryptophan Containing Peptides Triggered by Selectfluor®” Link (15 citations)

15. Jeedimalla, N.; Johns, J.; Roche*, S. P. Tetrahedron Lett. 2013, 54, 5845 – 5848. “Mechanistic Investigation and Implications of a Sacrificial Aniline for the Tandem Cascade Synthesis of 4-Aza-podophyllotoxin Analogues.” Link (4 citations)

Graduate and Postdoctoral Research:

14. Santagata, S.; Mendillo, M. L.; Tang, Y-C.; Perley, C. C.; Roche, S. P.; Kwon, H.; Koeva, M.; Subramanian, A.; Golub, T. R.; Amon, A.; Porco Jr., J. A.; Whitesell *, L; Lindquist *, S. Science 2013341, 250 – 260. “Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state.” Link  (74 citations)

​13. Lajkiewicz, N. J.; Roche, S. P.; Gerard, B.; Porco Jr.*, J. A. J. Am. Chem. Soc. 2012134, 13108 – 13113. “Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline.” Link (5 citations)

12. Porco Jr., J. A.; Pelletier, J.; Roche, S. P.; Cencic, R.; Rodrigo, C. PCT Int. Appl. (2011), WO 2011140334 A2 20111110  “Preparation of rocaglamide derivatives as antiproliferative agents ” Link

11. Rodrigo, C. M.; Cencic, R.; Roche, S. P.; Pelletier, J.; Porco Jr.*, J. A. J. Med. Chem. 201255, 558 – 562. “Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies”. Link (8 citations)

10. Roche, S. P.; Porco Jr.*, J. A. Angew. Chem. Int. Ed. 201150, 4068 – 4093. Review: “Dearomatization Strategies in Complex Natural Product Synthesis” Link (336 citations)

​9. Roche, S. P.; Cencic, R.; Pelletier, J.; Porco Jr.*, J. A. Angew. Chem. Int. Ed. 201049, 6533 – 6538. “Biomimetic Photocycloaddition of 3-Hhydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation”. Link Selected by the editors as a “Hot Paper”(31 citations)

​8. Roche*, S. P.; Aitken*, D. J. Eur. J. Org. Chem. 2010, 5339 – 5358. Review: “Chemistry of 4-Hydroxy-2-cyclopentenone derivatives”.  Link (33 citations)

7. Roche, S. P.; Teyssot, M-L.; Gautier*, A. Tetrahedron Lett. 201051, 1265 – 1268. “Synthesis of 1,2 Diamines under Environmentally Benign Conditions: Application for the Preparation of Imidazolidiniums”. Link (5 citations)

6. Faure*, S.; Hjelmgaard, T.; Roche, S. P.; Aitken*, D. J. Org. Lett. 2009, 11, 1167 – 1170. “Passerini Reaction-Amine Deprotection-Acyl Migration Peptide Assembly: Efficient Formal Synthesis of Cyclotheonamide C”. Link (33 citations)

5. Teyssot, M-L.; Jarrousse, A-S.; Manin, M.; Chevry, A.; Roche, S.; Norre, F.; Beaudoin, C.; Morel, L.; Boyer, D.; Mahiou, R.; Gautier*, A. Dalton Trans. 2009, 6894 – 6902. Perspective: “Metal-NHC complexes: a survey of anti-cancer properties”. Link (188 citations)

4. Roche, S. P.; Faure, S.; Aitken*, D. J. Angew. Chem. Int. Ed. 200847, 6840 – 6842. “Total Synthesis of Cyclotheonamide C using a Tandem Backbone-Extension–Coupling Methodology”. Link (5 citations)

3. Roche, S. P.; Faure, S.; El Blidi, L.; Aitken*, D. J. Eur. J. Org. Chem. 200830, 5067 – 5078. “Total Synthesis of Cyclotheonamide C by Use of an α-Keto Cyanophosphorane Methodology for Peptide Assembly”. Link (4 citations)

2. Nicolaou*, K. C.; Majumder, U.; Roche, S.P.; Chen*, D. Y.-K. Angew. Chem. Int. Ed. 200746, 4715 – 4718. “Construction of the “Left Domain” of Haplophytine”. Link (31 citations)

1. Aitken*, D. J.; Faure, S.; Roche, S. Tetrahedron Lett. 200344, 8827 – 8830. “Synthetic approaches to the Southern Part of Cyclotheonamide C”. Link (14 citations)