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Updated in May 2024

"A man may die, nations may rise and fall,

but an idea lives on."  John F. Kennedy

Independent Research @ FAU: 2011-present

42. Naylon, S. H.; Richaud, A. D.; Zhao, G.; Bui, L.; Dufresne, C. P.; Wu, C. J.; Wangpaichitr, M.; Savaraj, N. and Roche, S. P.  A Platform of ADAPTive Scaffolds: Development of CDR-H3 β-Hairpin Mimics into Covalent Inhibitors of the PD1/PDL1 Immune Checkpoint. J. Med. Chem. 2024, (Submitted) 




41. Guo, L.; Overholser, J.; Naylon, S. H.; Roche, S. P. and Kaumaya P. T. P.  Newly identified Chimeric CTLA-4 B-cell epitope peptide vaccines demonstrate an effective anti-tumor immunity alone or in combination with PD1/PDL1 blockade in breast and colorectal cancer models. Cancer Research. 2024, (Submission) 




40. Zhao, G.; Richaud, A. D.; Williamson, R. T.; Feig, M.; Roche, S. P. De Novo Synthesis and Structural Elucidation of CDR-H3 Loop Mimics. ACS. Chem. Biol. 2024, (Under Review) 




39. Scesa, P. D.; Roche, S. P.; West, L. Enantioselective Synthesis of (+)-Providencin and its Unexpected Regioisomer via a Biomimetic Norrish–Yang Cyclization from (–)-Bipinnatin E. Org. Lett. 2024, 26, 1123 Link 



38. Richaud, A. D.; Mandal, S.; Das, A.; Roche, S. P. Tunable CH/π Interactions within a Tryptophan Zipper Motif to Stabilize the Fold of Long β-Hairpin Peptides. ACS Chem. Biol. 2023, 18, 2555-2563  Link 


37. Moxam, J.; Naylon, S.; Richaud, A. D.; Zhao, G.; Padilla, A.; Roche, S. P. Passive Membrane Permeability of Sizable Acyclic β-Hairpin Peptides. ACS Med. Chem. Lett. 2023, 14, 278-284  Link

Featured Communication Cover Vol14, Issue 3 Link


36. Richaud, A. D.; Zaghouani, M.; Zhao, G.; Wangpaichitr, M.; Savaraj, N.; Roche, S. Exploiting the Innate Plasticity of the Programmed Cell Death-1 (PD1) Receptor to Design Pembrolizumab H3 Loop Mimics. ChemBioChem 2022, 23, e202200449  Link 


35. Richaud, A. D.; Zhao, G.; Hobloss, S.; Roche, S. P. Folding in Place: Design of β-Strap Motifs to Stabilize the Folding of Hairpins with Long Loops. J. Org. Chem. 2021, 86, 13535–13547 Link


34. Roche, S. P. In the pursuit of (ald)imine surrogates for the direct asymmetric synthesis of non-proteinogenic α-amino acids. Synthesis 2021, 53, 2767–2776 Link 


33. Roche, S. P. Recent Advances in Oxa-6π Electrocyclization Reactivity for the Synthesis of Privileged Natural Product Scaffolds. Organics 2021, 2, 376–387. Link

32. Scesa, P.; West, L. M.; Roche, S. P. Role of Macrocyclic Conformational Steering in a Kinetic Route toward Bielschowskysin. J. Am. Chem. Soc. 2021, 143, 7566–7577. Link


31. Richaud, A. D.; Roche, S. P. Structure–Property Relationship Study of N-(Hydroxy)Peptides for the Design of Self-Assembled Parallel β-Sheets. J. Org. Chem. 2020, 19, 12329–12342; Preprint ChemRxiv. DOI: 10.26434/chemrxiv.12486236.v1 Link


30. Zhao, G.; Samanta, S. S.; Michieletto, J.; Roche, S. P. A Broad Substrate Scope of aza-Friedel−Crafts Alkylation for the Synthesis of Quaternary α-Amino Esters. Org. Lett. 2020, 22, 5822–5827; Preprint ChemRxiv. DOI: 10.26434/chemrxiv.12111309.v1 Link


29. Bendelsmith, A. J.; Kim, S. C.; Wasa, M.; Roche, S. P.; Jacobsen*, E. N. Enantioselective Synthesis of α-Allyl Amino Esters via Hydrogen-Bond-Donor Catalysis. J. Am. Chem. Soc. 2019, 141, 11414–11419. Link 


28. Samanta, S. S.; Roche, S. P. Synthesis and Reactivity of a-Haloglycine Esters: Hyperconjugation in Action. Eur. J. Org. Chem. 2019, 6597–6605. Editor Choice Issue Cover: Link


27. Zaghouani, M.; Bögeholz, L. A. K.; Mercier, E.; Wintermeyer, W.; Roche, S. P.  Total synthesis of (±)-fumimycin and analogues for biological evaluation as peptide deformylase inhibitors. Tetrahedron 2019, 75, 3216–3230. Editor Invitation for the Tetrahedron Young Investigator Award Issue. Link


26. Shearer, C.; Desaunay, O.; Zorc, S.; Richaud, A. D.; Samanta, S. S.; Jeedimalla, N.; Roche, S. P.  Interrupted Knoevenagel Condensation for the Synthesis of Unsymmetrical Fused Tricyclic Dihydropyrans. Tetrahedron 2019, 130606  Link


25. Lepir, T.; Zaghouani, M.; Roche, S. P.; Li, Y. Y.; Suarez, M.; Irias, M. J.; Savaraj, N. Nivolumab to pembrolizumab switch induced a durable melanoma response: A case report. Medicine, 2019, 98, e13804-e13810. Link


24. Jeedimalla, N.; Jacquet, C.; Bahneva, D.; Youte Tendoung, J.-J.; Roche, S. P. Synthesis of α-Arylated Cycloalkanones from Congested Trisubstituted Spiro-epoxides: Application of the House–Meinwald Rearrangement for Ring Expansion. J. Org. Chem. 2018, 83, 12357–12373. Editor Choice Issue Cover


23. Scesa, P.; Wangpaichitr, M.; Savaraj, N.; West, L.; Roche, S. P. Angew. Chem. Int. Ed. 2018 , 57, 1316 – 1321“A Kinetic Dearomatization Strategy for an Expedient Route to the Bielschowskysin Skeleton” Link

22. Samanta, S. S.; Roche, S. P. J. Org. Chem. (full article) 2017, 82, 8514 – 8526. “In Situ-Generated Glycinyl Chloroaminals for a Verstatile One-Pot Synthesis of Non-Proteinogenic a-Amino Esters” Link

21. Hall, A.; Roche*, S. P.; West*, L. Org. Lett. 2017, 19, 576 – 579. “Synthesis of Briarane Diterpenoids: Biomimetic Transannular Oxa-6p electrocyclization Induced by a UVA/UVC Photoswitch.” Link (2 citations)

20. Jeedimalla, N.; Flint, M.; Smith, L.; Haces, A.; Minond*, D.; Roche*, S. P.  Eur. J. Med. Chem. 2015, 106, 167 – 179 “Multicomponent Assembly of 4-Aza-podophyllotoxins: A Fast Entry to Highly Selective and Potent Anti-Leukemic Agents.” Link (3 citations)

19. Wasa, M.; Liu, R. Y.; Roche*, S. P.; Jacobsen*, E. N. J. Am. Chem. Soc. 2014134, 13108 – 13113. “Asymmetric Mannich Synthesis of a-Amino Esters by Anion-Binding Catalysis.” Link (12 citations)

18. Roche*, S. P.; Samanta, S. S.; Gosselin, M. M. J. Chem. Commun. 2014, 50, 2632 – 2634 “Autocatalytic One Pot Orchestration for the Synthesis of α-Arylated α-Amino Esters.” Link (2 citations)

17. Roche*, S. P.; Youte Tendoung, J.-J.; Tréguier, B.; Tetrahedron 2014, 70, “Advances in Dearomatization Strategies of Indoles.” Review Article Link (66 citations)

16. Treguier, B.; Roche*, S. P. Org. Lett. 2014, 16, 278 – 281 “A Double Annulative Cascade of Tryptophan Containing Peptides Triggered by Selectfluor®” Link (15 citations)

15. Jeedimalla, N.; Johns, J.; Roche*, S. P. Tetrahedron Lett. 2013, 54, 5845 – 5848. “Mechanistic Investigation and Implications of a Sacrificial Aniline for the Tandem Cascade Synthesis of 4-Aza-podophyllotoxin Analogues.” Link (4 citations)

Graduate and Postdoctoral Research:

14. Santagata, S.; Mendillo, M. L.; Tang, Y-C.; Perley, C. C.; Roche, S. P.; Kwon, H.; Koeva, M.; Subramanian, A.; Golub, T. R.; Amon, A.; Porco Jr., J. A.; Whitesell *, L; Lindquist *, S. Science 2013341, 250 – 260. “Tight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state.” Link  (74 citations)

​13. Lajkiewicz, N. J.; Roche, S. P.; Gerard, B.; Porco Jr.*, J. A. J. Am. Chem. Soc. 2012134, 13108 – 13113. “Enantioselective Photocycloaddition of 3-Hydroxyflavones: Total Syntheses and Absolute Configuration Assignments of (+)-Ponapensin and (+)-Elliptifoline.” Link (5 citations)

12. Porco Jr., J. A.; Pelletier, J.; Roche, S. P.; Cencic, R.; Rodrigo, C. PCT Int. Appl. (2011), WO 2011140334 A2 20111110  “Preparation of rocaglamide derivatives as antiproliferative agents ” Link

11. Rodrigo, C. M.; Cencic, R.; Roche, S. P.; Pelletier, J.; Porco Jr.*, J. A. J. Med. Chem. 201255, 558 – 562. “Synthesis of Rocaglamide Hydroxamates and Related Compounds as Eukaryotic Translation Inhibitors: Synthetic and Biological Studies”. Link (8 citations)

10. Roche, S. P.; Porco Jr.*, J. A. Angew. Chem. Int. Ed. 201150, 4068 – 4093. Review: “Dearomatization Strategies in Complex Natural Product Synthesis” Link (336 citations)

​9. Roche, S. P.; Cencic, R.; Pelletier, J.; Porco Jr.*, J. A. Angew. Chem. Int. Ed. 201049, 6533 – 6538. “Biomimetic Photocycloaddition of 3-Hhydroxyflavones: Synthesis and Evaluation of Rocaglate Derivatives as Inhibitors of Eukaryotic Translation”. Link Selected by the editors as a “Hot Paper”(31 citations)

​8. Roche*, S. P.; Aitken*, D. J. Eur. J. Org. Chem. 2010, 5339 – 5358. Review: “Chemistry of 4-Hydroxy-2-cyclopentenone derivatives”.  Link (33 citations)

7. Roche, S. P.; Teyssot, M-L.; Gautier*, A. Tetrahedron Lett. 201051, 1265 – 1268. “Synthesis of 1,2 Diamines under Environmentally Benign Conditions: Application for the Preparation of Imidazolidiniums”. Link (5 citations)

6. Faure*, S.; Hjelmgaard, T.; Roche, S. P.; Aitken*, D. J. Org. Lett. 2009, 11, 1167 – 1170. “Passerini Reaction-Amine Deprotection-Acyl Migration Peptide Assembly: Efficient Formal Synthesis of Cyclotheonamide C”. Link (33 citations)

5. Teyssot, M-L.; Jarrousse, A-S.; Manin, M.; Chevry, A.; Roche, S.; Norre, F.; Beaudoin, C.; Morel, L.; Boyer, D.; Mahiou, R.; Gautier*, A. Dalton Trans. 2009, 6894 – 6902. Perspective: “Metal-NHC complexes: a survey of anti-cancer properties”. Link (188 citations)

4. Roche, S. P.; Faure, S.; Aitken*, D. J. Angew. Chem. Int. Ed. 200847, 6840 – 6842. “Total Synthesis of Cyclotheonamide C using a Tandem Backbone-Extension–Coupling Methodology”. Link (5 citations)

3. Roche, S. P.; Faure, S.; El Blidi, L.; Aitken*, D. J. Eur. J. Org. Chem. 200830, 5067 – 5078. “Total Synthesis of Cyclotheonamide C by Use of an α-Keto Cyanophosphorane Methodology for Peptide Assembly”. Link (4 citations)

2. Nicolaou*, K. C.; Majumder, U.; Roche, S.P.; Chen*, D. Y.-K. Angew. Chem. Int. Ed. 200746, 4715 – 4718. “Construction of the “Left Domain” of Haplophytine”. Link (31 citations)

1. Aitken*, D. J.; Faure, S.; Roche, S. Tetrahedron Lett. 200344, 8827 – 8830. “Synthetic approaches to the Southern Part of Cyclotheonamide C”. Link (14 citations)

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